Publications from the Lacefield Lab at IU
Gavade, JN, Puccia, CM, Herod, SG, Trinidad, JC, Berchowitz, LE, and Lacefield, S. Identification of 14-3-3 Proteins, Polo kinase, and RNA-binding protein Pes4 as Key Regulators of Meiotic Commitment in Budding Yeast. Current Biology (in press).
Gihana, GM, Cross-Najafi, AA, and Lacefield S. The mitotic exit network regulates the spatiotemporal activity of Cdc42 to maintain cell size. Journal of Cell Biology 220 (1):e202001016 (2021).
MacKenzie, AM, and Lacefield S. CDK regulation of meiosis: Lessons from S. cerevisiae and S. pombe. Genes 11 (7): E723 (2020).
Cairo G, and Lacefield, S. Establishing correct kinetochore-microtubule attachments in mitosis and meiosis. Essays in Biochemistry EBC20190072 (2020).
Cairo, G, MacKenzie, A, and Lacefield, S. Differential requirement of Bub1/Bub3 in the regulation of meiotic versus mitotic chromosome segregation. Journal of Cell Biology 219(4) e201909136 (2020).
Wang, F, Zhang, R, Feng, W, Tsuchiya, D, Ballew, O, Li, J, Denic, V, Lacefield, S. Autophagy of an amyloid-like translational repressor regulates meiotic exit. Developmental Cell 52:141-151 (2020).
Ballew, O, and Lacefield, S. The DNA damage checkpoint and the spindle position checkpoint maintain meiotic commitment in Saccharomyces cerevisiae. Current Biology (2019).
Lacefield, S. Detaching the tether: remodeling mitochondrial localization during meiosis. Journal of Cell Biology. 218(2) (2019).
Barsh GS, Bhalla N, Cole F, Copenhaver GP, Lacefield S, Libuda DE. 2018 PLOS Genetics Research Prize: Bundling, stabilizing, organizing- The orchestration of acentriolar spindle assembly by microtubule motor proteins. PLOS Genetics 14(9):e1007649 (2018).
Gihana GM, Musser TR, Thompson O, and Lacefield, S. Prolonged CDK inhibition results in septin perturbations during return-to-growth and mitosis. Journal of Cell Biology 217(7): 2429-2443 (2018).
Lacefield, S. Chromosome biology: specification of the kinetochore for cohesion recruitment. Current Biology 27 (24): R1319-R1321 (2017).
Falk JE, Tsuchiya D, Verdaasdonk J, Lacefield S, Bloom K, and Amon, A. Spatial signals link exit from mitosis to spindle position. eLIFE 2016; 10.7554/eLife.14036
Yang Y, Tsuchiya D, and Lacefield, S. Bub3 promotes Cdc20-dependent activation of the APC/C in S. cerevisiae. Journal of Cell Biology 209 (4):519-527 (2015).
Ho KH, Tsuchiya D, Oliger AC, and Lacefield, S. Localization and function of budding yeast CENP-A depends on kinetochore protein interactions and is independent of canonical centromere sequence. Cell Reports 9(6):2027-33 (2014).
Tsuchiya, D. Yang, Y. and Lacefield, S. Positive Feedback of NDT80 expression ensures irreversible meiotic commitment in budding yeast. PLOS Genetics 10 (6):e1004398 (2014).
Lacefield, S. CDK modulation coordinates G1 events after S phase. Cell Cycle 13:5 1-2 (2014).
Tsuchiya, D. and Lacefield, S. Cdk1 modulation ensures the coordination of cell cycle events during the switch from meiotic prophase to mitosis. Current Biology 23 1505-1513 (2013).
Lacefield, S. Helping chromosomes and chromatids stay on track. Elife 10.7554/eLife.00386 (2012).
Tsuchiya, D. Gonzalez, C. and Lacefield, S. The spindle checkpoint protein Mad2 regulates APC/C activity during prometaphase and metaphase of meiosis I in Saccharomyces cerevisiae. Molecular Biology of the Cell 22(16) 2848-61 (2011).
Previous Publications:
Lacefield, S. Lau, D., and Murray, AW. Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast. Nature Cell Biology 11(9) 1116-1120 (2009).
Lacefield, S. and Murray, AW. The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere. Nature Genetics 39(10) 1273-1277 (2007).
Lacefield, S. and Solomon, F. Consequences of defective tubulin folding on heterdomer levels, mitosis, and spindle morphology in S. cerevisiae. Genetics 173(2) 635-46 (2006).
Lacefield, S. and Ingolia, N. Signal Transduction: external signals influence spore-number control. Current Biology 16 (4), R125-7 (2006).
Lacefield, S and Murray, A. A delay like no other. Nature Genetics 37(7), 662-3 (2005).
Lacefield S. and Solomon, F. An early step in b-tubulin folding affects tubulin heterodimer levels. Genetics 165(2), 531-41 (2003).
(Lacefield) Shimoda, S.L. and Solomon, F. Integrating functions at the kinetochore. Cell 109, 9-12 (2002).
Koehler KE, Boulton CL, Collins HE, French RL, Herman KC, Lacefield SM, Madden LD, Scheutz CD, Hawley RS. Spontaneous X chromosome MI and MII nondisjunction events in Drosophila melanogaster oocytes have different recombinational histories. Nature Genetics 14, 406-414 (1996).